What is Tapentadol 100mg used for? Tapentadol Aspadol 100mg is used to treat severe pain and should only be used when other forms of non-opioid pain relief have not been successful in managing pain or are not tolerated. Tapentadol is not usually recommended for the How does Tapentadol work? Tapentadol Aspadol 100mg works directly on opioid receptors in the central nervous system and reduces feelings of pain by interrupting the way nerves signal pain between the brain and the body. Once Your order is placed we will verify Your order and guide You futher steps. Communicate to your doctor about medication to assist stop or treat constipation caused by Tapentadol in case your signs do not go away. As with all opioids, Tapentadol acts directly on the central nervous system, blocking ache alerts from the nerves to the brain; but it additionally enhances the results of two mind messengers, serotonin and noradrenaline.